Just minutes after taking off from New York's JFK Airport, TWA Flight 800 is ripped apart by a massive explosion. With a possible terror attack on their hands, the FBI joins investigators from the NTSB in an urgent search for answers. Both agencies are hoping for quick results, but the investigation into TWA Flight 800 will eventually pit them against one another, and will turn into one of the longest, most costly and challenging ever conducted.

On 26 September 1997, Garuda Indonesia Flight 152 crashes into mountainous woodlands while trying to land at Polonia International Airport in Medan, North Sumatra, in low visibility. All 234 people on board are killed.

On 31 October 2015, Metrojet Flight 9268 disintegrates in mid-air and crashes into the Sinai Peninsula during a routine chartered flight from Sharm El Sheikh International Airport to Pulkovo Airport, killing all 224 people on board.

On 31 July 1992, Thai Airways International Flight 311 crashes into a mountain while on final approach to Tribhuvan International Airport in Kathmandu, Nepal, in poor weather conditions, killing all 99 passengers and 14 crew members on board.

On 31 August 1999, LAPA Flight 3142 overruns the runway and crashes while taking off from Aeroparque Jorge Newbery in Buenos Aires, Argentina, killing 63 of the 100 people on board and 2 on the ground.

After a routine one-hour flight from Minneapolis, Northwest Airlink Flight 5719 crashes in northern Minnesota, killing everyone on board. Investigators face intense pressure to find the cause. The cockpit voice recorder raises disturbing questions about an inexperienced pilot. But as investigators dig deeper, they uncover a troubling pattern of abuse that led to a breakdown in human cooperation.

On 4 February 2015, TransAsia Airways Flight 235 strikes a viaduct and crashes into the Keelung River shortly after takeoff from Taipei Songshan Airport, killing 43 of the 58 people on board.

When a commuter flight to Detroit ends in a harrowing death spiral, it's up to investigators to determine the cause and prevent it from ever happening again. They sort through the shattered wreckage in search of clues, and a close analysis of the flight data eventually leads them to a stunning realization-What doomed Flight 3272 is a danger the industry has known about for years.

On 2 July 1994, USAir Flight 1016 stalls and crashes into a residential area while attempting to land at Charlotte/Douglas International Airport during a thunderstorm, killing 37 of the 57 people on board.

Headed for South Korea's Gimhae International Airport, a Boeing 767 crashes into a hillside several miles from the runway. As the nation mourns its worst-ever air disaster, investigators face puzzling evidence: The surviving captain of Air China Flight 129 claims that everything on board was normal, but air traffic controllers testify that the crew's radio communications were anything but.