On 25 July 2000, a Concorde operating as Air France Flight 4590 en route to New York City, USA, stalls and crashes into a hotel in Gonesse shorty after take off from Charles de Gaulle International Airport. The plane had struck foreign debris from a Continental Airlines DC-10 causing the plane's fuel tanks to ignite and the engines to fail. All of the 109 passengers and crew die in the incident and 4 on the ground.

On 26 May 1991, the thrust reverser of the first engine of Lauda Air Flight 004 accidentally deploys in mid-flight causing the plane to spiral out of control and disintegrate about 100 miles northwest of Bangkok. All of the 223 passengers and crew die in the crash.

On 3 September 1989, the pilots of Varig Flight 254 enter an incorrect heading into the flight computer. Instead of flying towards its destination, the aircraft flies west and after some time is over a remote area of the Amazon jungle. Attempts to reach an alternative airport are unsuccessful, and the aircraft eventually runs out of fuel. The pilot makes a belly landing in the jungle where 13 people die.

On 8 January 1989, British Midland Flight 92 crashes onto the embankment of the M1 motorway near Kegworth, Leicestershire, UK. The aircraft was attempting to conduct an emergency landing at East Midlands Airport. Of the 126 people aboard, 47 died and 74, including seven members of the flight crew, sustained serious injuries.

Copa Airlines Flight 201 is flying towards Cali, Colombia when the plane suddenly disintegrates in mid-air.

FedEx Express Flight 14 crash lands at Newark but the pilots survive but years later, FedEx Express Flight 80 experiences a similar but fatal crash.

On 4 November 2008, an official Mexican Interior Ministry Learjet 45 crashes in central Mexico City. Mexican Secretary of the Interior Juan Camilo Mouriño, who was aboard the plane, was killed in the crash, along with the other seven people on board and eight people on the ground. The plane crashed in rush-hour traffic at Las Lomas. The plane crashed due to a loss of control from wake turbulence.

On 10 February 2011, Manx2 Flight 7100 crashes at Cork Airport in Ireland after the pilots lose control of the aircraft in an attempted go-around in low visibility. Six of the twelve people on board are killed in the crash.

On 20 August 2011, First Air Flight 6560, a charter flight, crashes near its destination of Resolute Bay Airport, Resolute, Nunavut, Canada, in poor weather conditions. Out of the fifteen passengers and crew members, only three survived.

On 8 March 2014, Malaysia Airlines Flight 370 disappears en route from Kuala Lumpur to Beijing with 239 passengers and crew on board. As of February 2015, no trace of the Boeing 777-200ER had been found, and speculation is that it crashed in the southern part of the Indian Ocean.

On 16 July 1999, John F. Kennedy Jr. dies when the Piper Saratoga light aircraft he is piloting crashes into the Atlantic Ocean off the coast of Martha's Vineyard, Massachusetts, in hazy conditions. His wife, Carolyn Bessette-Kennedy, and sister-in-law, Lauren Bessette, are on board and are also killed. The NTSB concluded that the crash was caused by spatial disorientation resulting in pilot error.