Larry takes an unflinching look at the sexual assault allegations against Bill Cosby with panelists Jamilah Lemieux, Kathleen Madigan, Baratunde Thurston and Keith Robinson.

Larry discusses the 2015 State of the Union address as well as the image and legacy of President Obama with panelists Jon Lovett, David Remnick, Amy Holmes, and Godfrey.

Larry discusses the changing state of U.S.-Cuba relations with panelists John Leguizamo, Soledad O'Brien, Mauricio Claver-Carone and Mike Yard.

Larry talks about the Disneyland measles epidemic and the fight against vaccines with panelists Holly Phillips, Judy Gold, Zoey O'Toole and Mike Yard.

Larry tackles the Deflategate scandal and dishonesty in professional sports with panelists Jake Tapper, Katie Nolan, Sherrod Small and Seaton Smith.

Larry addresses the debate over genetically engineered babies with panelists Gabrielle Union, Penn Jillette, Holly Phillips and Rachel Feinstein.

Larry discusses the Koch brothers and the flood of private money in political campaigns with panelists Zephyr Teachout, David Webb, Hari Kondabolu and Ted Alexandro.

Panelists Common, Charles Blow, Joe Jones and Mike Yard join Larry for an in-depth discussion of African-American fatherhood.

Larry discusses the backlash over the Oscar nominations' lack of diversity and the success of recent protests with Cory Booker, Talib Kweli, Bill Burr, and Shenaz Treasury.

Larry takes a look at the controversy swirling around the movie "American Sniper" with panelists Matt Taibbi, Paul Rieckhoff, Sabrina Jalees and Nick Irving.

Panelists Lance Bass, Sally Kohn, Jessica Kirson and Michel Faulkner join Larry to talk about America's growing acceptance of same-sex marriage.

Panelists Retta, Anne-Marie Johnson, Deborah Tillman and Pete Dominick discuss free-range parenting, government overreach and child discipline.

Sunny Hostin, Phillip Agnew, Michael Skolnik and Godfrey discuss the disturbing findings from a Department of Justice's report on the Ferguson, MO, police department.

Larry tackles viewers' questions about the anti-vaccine movement, obesity and beauty standards with Anthony Anderson, S.E. Cupp, Michaela Pereira and Rory Albanese.

Panelists Michael McKean, Kimberly Dozier, Negin Farsad and Wes Moore join Larry for a discussion about ISIS as well as the U.S.'s foggy relationship with war.

Larry talks Islamophobia and Muslim extremism with panelists Ahmed Shihab-Eldin, Dean Obeidallah, Reggie Love and Shenaz Treasury.

Larry reacts to an Oklahoma fraternity's racist chant and discusses equal opportunity for women with panelists Alicia Menendez, Egypt Sherrod, Chloe Hilliard and Jim Norton.

Larry talks about the significance of the proposed Mars One expedition with Don Cheadle, Sonia Van Meter, Ricky Velez and Lee Daniels.

Adam Carolla, Carl Hart, Roland Martin and Michelle Buteau join Larry to talk about the growing acceptance of legalizing marijuana in the U.S.

Issa Rae, Christina Greer, Jacque Reid and Marina Franklin join Larry to discuss issues black women face in the workplace as well as the pros and cons of interracial dating.

Panelists Martin Short, Frank Rich, Big Sean and Tara Setmayer weigh in on Rudy Giuliani's claim that President Obama doesn't love America.

Cedric the Entertainer, Daymond John, Ted Alexandro and Maria Hinojosa discuss the Apple Watch and the ethical issues faced by consumers of modern technology.

Larry addresses America's obesity problem with panelists Morgan Spurlock, Marianne Kirby, Lavell Crawford and Shannon DeVido.

New York City Mayor Bill de Blasio sits down with Larry to discuss income inequality, police-community relations and the city's marijuana laws.

Joy Reid, Bonnie McFarlane, Megan Powers and Emma Iannini join Larry for a debate about legalizing guns on college campuses.