Stardate: Unknown. Sisko leads, what he hopes will be, a final all-out assault on Cardassia Prime. Kira and Garak mount a suicidal assault on the Cardassian headquarters occupied by the Dominion, who in turn kill innocent women and children village by village in retaliation for the Resistance's attacks.

Stardate: Unknown. Odo is affected by the disease threatening to eliminate his race more than he lets on. Kira has to deal with the Cardassian's dislike of her. Even though General Martok sees Chancellor Gowron's move as part of a political vendetta, he does nothing about it.

Stardate: Unknown. Capt. Sisko and his away team volunteer to stay with a besieged unit at an isolate outpost.

Stardate: Unknown. Severely depressed at his serious war wound, Nog retreats into Vic Fontaine's holosuite program while the singer tries to help him.

Stardate: Unknown. Dr. Bashir is contacted again by Sloan of Section 31, who wants him to gather intel at an upcoming Romulan medical conference. Sisko agrees to send him, in order to learn more about Section 31 themselves.

Stardate: Unknown. After the Breen attack Earth there are mixed emotions abound on DS9. Having revealed her secret regarding the Prophets to the disguised Dukat, Kai Winn turns her back on them, only to be convinced by Dukat to embrace the Pah Wraiths. On the home world of Cardassia, Legate Damar mounts a resistance to the Dominion.

Stardate: Unknown. A Vorta offers Odo valuable information on the Dominion in exchange for asylum. Meanwhile, Nog tries his Ferengi knowledge as he wheels and deals for a valuable piece of equipment for Chief O'Brien.

Stardate: 52861.3. Odo begins his recovery from the deadly disease as Dr. Bashir informs him of Section 31's intentions of wiping out his race. A resistance mission goes bad for Kira and Garak and they end up hiding in the basement of the house that Garak grew up in, where they learned that Legate Damar has apparently become a casualty of war, despite him also hiding with them. Quark is chosen by the Grand Nagas as his successor upon his impending retirement to Risa.

Stardate: Unknown. Kira is sent to Cardassia to train their resistance. Dr. Bashir discovers that Odo has contracted the same disease threatening the Founders. Gowron arrives on DS9, announcing he’s taking control of the Klingon fleet from Martok.

Stardate: 52152.6. Ezri Dax joins Sisko and his family on his quest for the Orb of the Emissary. Jadzia's friends and family seek a glorious battle that will earn her place in Sto-vo-kor. Kira gambles the alliance with Romulans by blockading their weapons installation on Bajor's moon.

Stardate: Unknown. Kai Winn gets unknowingly involved with Gul Dukat, disguised as a Bajoran. Tensions rise between Weyoun and Gul Damar as the Dominion gather to sign a peace treaty with the Breen. Ezri and Worf are captives on Cardassia.

Stardate: 52645.7. Dr. Bashir and Chief O'Brien go to extreme measures to try and track down a cure for Odo.

Stardate: Unknown. An aged Kor requests an opportunity to die with honor as a warrior.

Stardate: Unknown. A hidden feature in Vic’s holosuite program causes the casino to be taken over by mobsters, and the DS9 crew plan a heist to take back their favorite hangout spot.

Stardate: Unknown. Sisko, laying low on Earth since the wormhole's disappearance, receives a vision of an unfamiliar woman he believes is the key to regaining contact with the Prophets. Meanwhile, Kira faces the challenge of commanding Deep Space Nine and upholding the fragile alliance with the Romulans, and Worf must cope with the loss of Jadzia Dax.

Stardate: Unknown. A Vulcan captain challenges Sisko to a game of baseball.

Stardate: Unknown. The Prophets disapprove of Sisko’s upcoming marriage, and he must make hard choices about his priorities. Ezri and Worf are captured by Dominion forces. Gul Dukat, disguised as a Bajoran, infiltrates DS9 and becomes close to Kai Winn.

Stardate: 52576.2. When the ship Worf was serving on is attacked in battle and all search efforts are abandoned, Ezri takes a runabout in search of him against Sisko's orders. Meanwhile, Sisko proposes to Cassidy Yates.

Stardate: Unknown. Ezri Dax struggles to adjust to her new joined identity and her complicated relationships with Jadzia's friends. Meanwhile, Garak tries to deal with a severe bout of claustrophobia.

Stardate: 51474.2. A changeling arrives who, like Odo, says he’s grown up among humanoids with no knowledge of the Founders. He tries to convince Odo to leave humanoid society and live among changelings.

Stardate: Unknown. Dr. Bashir’s genetically engineered friends return to the station, seeking his help in rousing one of them from her catatonic state.

Stardate: Unknown. Kira is kidnapped and taken to Empok Nor by a member of a Pah'Wraith cult and discovers the group leader is Gul Dukat.

Stardate: Unknown. When a murder on the station stumps the crew, Ezri Dax reluctantly seeks help from the residual consciousness of the host she’d rather forget, the murderer Joran.

Stardate: Unknown. Ezri travels to her family home in search of Chief O'Brien who has discovered a murdered woman connected with the family and the Orion Syndicate.

Stardate: Unknown. Quark and Rom have to rescue Grand Nagus Zek who is being held captive in the Alternate Universe.