James and the Bunker Hill surgeons attempt to make medical history with the largest chain of internationally paired kidney donations ever, comprised of eight simultaneous organ transplants and 16 surgeries.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.

Walter and the Bunker Hill surgeons must perfect a revolutionary remote surgery when someone on the International Space Station needs an emergency procedure.

James and Zoe work to help a teenage girl with a rare skin blistering disorder, employing radical treatments to heal her skin in time for her to attend her school prom. Also, as Louis Keating’s GSS condition gets worse, James is tempted to use his experimental cure to save him.

Angie tries to target her mother’s illness using radical nanobot technology, but she looks to Scott for help when her mother prefers using traditional methods. Also, when a graffiti artist with a clotting disorder falls from a bridge, Walter, Malik and Zoe attempt to use suspended animation to stop his internal bleeding.

Talaikha and Malik treat Georgia Ray, one of the world’s biggest pop stars and friend of James’s, for laryngeal cancer, but when gold particles and microsurgery reveal more cancer than expected, they incur the singer’s wrath when her vocal chords and career are threatened.

Malik and Zoe don't see eye to eye when it comes to using a revolutionary procedure involving spider silk to save a boy's crushed legs versus the safer route of amputation. Elsewhere, James, Walter and Talaikha care for a young woman in desperate need of a liver transplant who, to their surprise, is reluctant to accept a donation from her estranged father.

When a young man comes to Bunker Hill ravaged by a drug-resistant strain of HIV, James attempts a radical anti-viral treatment. Also, Walter must work quickly when his daughter’s best friend contracts a fatal flesh-eating bacteria, and James makes a connection with Louis Keating’s nurse.

When a woman arrives at Bunker Hill with a mysterious lung ailment, James is conflicted after he connects other respiratory cases in her area to possible contamination from a microchip factory owned by his hero, tech guru Douglas Prescott.

Silicon Valley tech titan James Bell enlists Dr. Walter Wallace, an exceptional veteran surgeon with a controversial past, to run his state-of-the-art hospital with an ultramodern approach to medicine.

James wants to treat a police officer who suffered a brain injury in a car crash and lost all of his memories with a cutting-edge method to recode his brain; at the same time, an obese woman is given an appetite suppression sensor; and Zoe tries to erase security footage of her kiss with Malik.

James convinces a hockey player with a severe spinal injury to undergo risky surgery that could enable him to walk again. Also, James invites Walter’s wife, FDA executive Julianna Wallace, to Bunker Hill to persuade her to approve a new skin bio-printing trial.

When a young leukemia patient comes to Bunker Hill in need of a miracle, James hopes a new t-cell cancer treatment will save her life, as her optimism inspires him to become a better person.