With his colleague sentenced to hang for murder, Detective Murdoch races to exonerate them and steps into a trap set by the real killer.

Two bank safe deposit boxes that were being transferred are taken by thieves and the crime is investigated by Detective Murdoch. The getaway driver for the thieves is killed.  While on scene someone claiming to be Sherlock Holmes shows up and provides some helpful information.  Dr. Ogden figures out that he is actually David Kingsley who at one time was treated for mental illness.  "Sherlock Holmes" appears to have the qualities of the fictional character of the same name such as the ability to "read" an individual or a crime scene.

Murdoch enlists some revealing detective work while investigating a murder at a nudist community.

Detective Murdoch and his methods are compromised when one of his colleagues is implicated in a suspicious murder.

Murdoch investigates the crash of a flying machine that killed a man, uncovering conspiracy and sabotage.

Murdoch films a street corner to catch a killer.

A toxic gas will be released into the city of Toronto, unless Murdoch can find a way to stop it.

Murdoch investigates the murder of an Eaton's department store manager who was disliked by the shop girls.

While investigating the death of a politician, rumored to have been killed by a vengeful ghost, Crabtree's theories of the paranormal conflict with Murdoch's scientific beliefs.

Detective Murdoch suspects a soldier after a veteran is slain by a sword.

A murder investigation is hindered by an uncooperative witness.

Murdoch investigates multiple drownings of a single career woman.

A delusional woman is the prime suspect in the stabbing of her fiance.