Chelsea kicks off a whole new journey of discovery and delinquency with guests Drew Barrymore, Chris Martin and the U.S. secretary of education.

Chelsea talks lube with Gwyneth Paltrow and lobbying with Tony Hale, tests her acting chops in a telenovela, and learns the secret to an ace TED talk.

Chris Evans and the "Civil War" cast dish on superhero culture and Hollywood's blind spots, and Chadwick Boseman schools Chelsea on Black Panther.

Chelsea talks tour life with Gwen Stefani, steps out with a colorful Harajuku squad, and studies the moon with NASA's "Mohawk Guy," Bobak Ferdowsi.

Chelsea delves into the U.S. presidential race with comedian Wanda Sykes, former Obama speechwriter Jon Favreau and a posse of senior Florida voters.

Chelsea reaches for a big note with the Grammy-winning "Voice" coach and steps into the rink with a pair of Russian figure skaters.

Senator Boxer and African-American churchgoers break down what's at stake in the 2016 election. Snapchat guru DJ Khaled preaches the keys to success.

Recovering addicts warn of porn's troubling side effects, and the "Crazy Ex-Girlfriend" star charts her journey from despair to a Golden Globe.

The actor-turned-mogul shares investing tips and joins Cindy McCain to shed light on human trafficking. Chelsea steps out as a dog walker for hire.

Avowed non-parent Chelsea grills Kate Hudson and others about the appeal of raising kids and has her nails done by a gender-nonconforming 9-year-old.

The Science Guy weighs in on Chelsea's cryotherapy experiment and his new thinking on GMOs. "Masters of Sex" star Lizzy Caplan performs a magic trick.

MSNBC's Jacob Soboroff explains the fuss over superdelegates, and astrology maven Megan Fox tries to make sense of mixed signals in Chelsea's chart.

Chelsea dives into a grueling mud race, Will Arnett puts a new spin on Trump's tweets, and "Daily Show" Hasan Minhaj talks Indian toilets.

Chelsea talks threesomes with the 'Do-Over' star, waits tables with her niece, and gets the inside scoop on Melissa Arnot's historic Everest feat.

The rapper joins California Lt. Governor Gavin Newsom to push for game-changing action on pot. Chelsea tries working out stoned with an MMA fighter.

Chelsea delves into the world of "Narcos" with star Wagner Moura and real-life DEA agent Javier Peña. Ariana Huffington warns of sleeping pill risks.

The actress opens up about her LGBT travel show and the devastating toll of the Orlando shooting. Also featuring Florence Henderson, Von Miller.

Chelsea gives Mexican teens a whack at Donald Trump, while Keith Olbermann sizes up the candidate's psyche. Anna Faris and Allison Janney talk Kegels.

"People v. O.J." star Sarah Paulson praises Marcia Clark. Nancy Pelosi calls for action on guns. Jason Biggs and Jenny Mollen share wild travel tales.

"Walking Dead" star Norman Reedus gives Chelsea a taste of motorcycle culture. Strahan talks flirting, good fortune and his new underwear line.

Comedians Adam Devine and Maria Bamford talk stand-ups, psych wards and success. Chelsea tries a mindful coloring session with Metta World Peace.

The actress details a hair-raising outing in Hawaii. Comedian Jim Gaffigan responds to the backlash over his manicure tweet. Plus, modern dating tips.

The country star reveals how girlfriend Gwen Stefani upstaged him on his birthday. Former congressman Barney Frank shares his ideal Democratic ticket.

Alexander Skarsgård reveals his punishing 'Legend of Tarzan' diet, Aubrey Plaza fantasizes about freeing dolphins, and Chelsea studies the red planet.

Chelsea sips mezcal with actor Diego Luna, gets a history lesson from Eva Longoria and grills former Mexican president Fox on bullfighting and Trump.

Melissa McCarthy and Chelsea recall the rocky road to show biz success. Van Jones slams Trump's recklessness and nepotism. With the "Nobodies" cast.

Chelsea talks resilient women with Charlize Theron, civic engagement with Rep. Linda Sánchez and "the French Donald Trump" with voters in Paris.

Tracee Ellis Ross, Aisha Tyler and Rosario Dawson join Chelsea to scorch Trump's first 100 days in office. Sen. Cory Booker urges political integrity.

Jim Parsons, Rashida Jones, Gaby Hoffmann and Mary McCormack celebrate teachers who impacted their lives. With former Education Secretary John King.

Chelsea quizzes “Guardians of the Galaxy” star Chris Pratt. Amy Schumer, Goldie Hawn and Wanda Sykes play a guessing game. Plus, Rep. Adam Schiff.

Leah Remini dissects the perils of leaving Scientology, Geoffrey Rush talks Einstein and acting with monkeys, and Danny McBride riffs on movie aliens.

Priyanka Chopra discusses "Baywatch" and self-esteem. Anthony Anderson reflects on racial identity. Sen. Elizabeth Warren champions higher wages.

Sen. Al Franken brings his humor to Congress. Sarah Silverman stands up for women's health issues. Plus, Thomas Middleditch on global warming.

Chelsea gives English etiquette a whirl, goes boating with Eddie Izzard, scrums with a pro rugby team and hits the pub to gauge opinions about Brexit.

Salma Hayek Pinault talks massage and marriage. CNN's Don Lemon discusses truth in journalism. Jerrod Carmichael gets real about the N-word.

Alison Brie and Betty Gilpin dish on wrestling training for "GLOW." Elisabeth Moss ponders real-life echoes of "The Handmaid's Tale." With Janet Mock.

NFL stars Russell Wilson and Kurt Warner, gymnast Aly Raisman and boxer Laila Ali reflect on competing, performance nerves and reinventing themselves.

Chelsea quizzes Harry Styles, chats with singer Rita Ora and talks "Game of Thrones" sexual taboos with John Bradley. With "Pod Save America" hosts.

Actress Cara Delevingne works to empower girls, tech leaders weigh in on cutting-edge automation, and Garbiñe Muguruza savors her big Wimbledon win.

Kate Beckinsale, Jill Soloway and Niecy Nash extol diversity in showbiz. Congressmen Ted Lieu and Eric Swalwell discuss immigration and impeachment.

Chelsea discusses Indian culture with actress Freida Pinto, haggles in a Mumbai market with Vikas Khanna, meets a guru and shakes it Bollywood-style.

Reese Witherspoon talks about her new movie and becoming a producer. Kathy Bates discusses "Disjointed" and medical marijuana. With Dan Rather.

James Corden chats musicals and public nudity, Bella Thorne hopes to inspire the next generation, and Sen. Kirsten Gillibrand addresses gun violence.

Jessica Biel gets real about motherhood. Chelsea kayaks with Abbi Jacobson and Ilana Glazer. With S.E. Cupp, Evan McMullin and Andrea Savage.

Emma Stone and Billie Jean King talk “Battle of the Sexes.” Justin Hartley reflects on his Hollywood success. Plus, grassroots politician Randy Bryce.

The NFL's Reggie Bush and activist DeRay Mckesson discuss athletes' defiant response to Trump. Maggie Gyllenhaal talks "The Deuce." Plus, Macklemore.

Kevin Hart and the Plastic Cup Boyz joke about comedy. Activists Kris Brown and Igor Volsky voice an urgent plea for gun control. Jackie Chan sings.

Dennis Quaid steps up for hurricane relief, Nancy Pelosi extols women's surging political clout, and Chrissy Metz mulls the impact of "This Is Us."

Jennifer Garner, Rob Riggle, Regina King, Mary McCormack and Dan Savage discuss their roots, patriotism, religion and modem America's complexities.

Gwen Stefani shares her love of Christmas music. Justice Bridget McCormack and activist Jason Kander talk the U.S. court system and voter suppression.