An unexpected turn of events leads to a wedding being hastily arranged. Shelagh finally goes into labour. The arrival of the pill leads to unforeseen consequences.

Nonnatus House welcomes a new recruit, Nurse Valerie Dyer. A vulnerable young man captures Fred and Violet's hearts, whilst the whereabouts of Sister Mary Cynthia is a concern.

Dr Turner helps the Mullucks cope with the stresses of caring for a disabled child as the terrible legacy of thalidomide becomes apparent and Nurse Crane faces an unexpected crisis.

An explosion at the docks brings heartache to the people of Poplar, whilst Sister Ursula continues to ruffle feathers with her unpopular decisions.

The winds of change are blowing through Poplar, as a new government paper calls for the eradication of small hospitals in favour of large general hospitals. Dr Turner and Shelagh are informed that an inspection of the maternity home will decide its fate.

Valerie Dyer cares for a pregnant Somali woman and is shocked by aspects of this unfamiliar culture. The nuns and midwives try to provide the best care for Sister Mary Cynthia.

The team reunite but all is not well when a change of management shakes up Nonnatus House.

An expectant mother with financial struggles enters into a painful arrangement with her cousin. As Tom provides pastoral care, he reveals why this case touched him more than most.