In the run-down slums of a futuristic city, the boxer only known as Junk Dog is making a living throwing fights for the mob in underground arenas. That all changes when he has a chance encounter with the champion, Yuri.

Yuri has sought Junk Dog out to test his mettle in the ring, and their encounter will leave the underground fighter a changed man.

Nanbu and Joe are preparing for their first official match, but in order to do that, they'll need to find a decent set of Gear first. While searching, they run into a group of orphan boys, thieving their way through life.

Crime boss Fujimaki has decided that Team Nowhere needs to throw their opening match in Megalonia in order to repay their debt to him. Can the team survive this blow to their ambitions? And even if they do, and Joe wins, will they survive the gangster's wrath?

JD faces off against his first opponent, hothead Shark ‘Maneater’ Samejima, with a revolutionary gimmick that will take the rest of the boxing world by storm!

When JD receives a fight request from a top tier Megalo Boxer, Team Nowhere can’t believe their luck. But when the boxer in question is revealed to be an old acquaintance of Nanbu, he is forced to come to terms with some past demons he’d thought he’d long since buried.

Aragaki is a formidable fighter who aims to destroy Joe at the watchful eye of Nanbu, but Joe will not give up and will follow the teachings of his coach until the end

There's one month until Megalonia begins, and it looks like Shirato Yukiko's brother, Mikio, is a lock for the final entrant into the tournament. Will Joe and Team Nowhere find a way to secure their spot in the Megalo Box championship tournament?

Shirato Mikio has forced Team Nowhere to forfeit a match by threatening to expose Joe and Nanbu's seedy past. Will their dream of making it into the Megalonia tournament ever come true?

It's man vs machine, as "Gearless" Joe squares off against Shirato Mikio, who is guided by Ace, an artificial intelligence of his own design.

Joe faces off against the bloody lion, Glen Burroughs. If he wants his friends to live, he'll have to throw the match. After coming this far... is there nothing else Team Nowhere can do?

Inspired by Joe's meteoric rise, and wanting to face him in a fair fight, Yuri makes a decision that will change everything for himself and Yukiko.

Joe has risen to the top and finally gets his chance of a rematch with Yuri. Yuri himself also feels joy in his chance to fight with Joe. The final battle begins!

Years after his victory at Megalonia, Joe has become a completely different man, going from one underground ring to another, now fighting as the wandering boxer Nomad.

Joe gets his motorcycle stolen by a boy named Mio and ends up at a settlement for immigrants where he runs into Chief again.

Joe helps Chief get ready to fight in the upcoming tournament while dealing with is own demons.

Chief fights in the last match of the tournament. Will he be victorious?

Joe heads back home to face his past.

Sachio ends up injuring a Megalo-boxer after they caused trouble at Bonjiri's shop. In retaliation, the Megalo-boxer comes back and trashes the place and steals the deed to the shop.

Liu finds out Joe is back in town and asks him to be his sparring partner. Mac Rosario had once lost everything, but made a miraculous comeback as the local hero.

Mac and Liu face off in the ring finally. Maya goes to talk to Sakuma after she finds Mac acting strange.

Joe continues to try to rebuild Gym Nowhere and Yukiko has some questions for Sakuma about BES.

The executives don't like Yukiko's decision to possibly end the company's partnership with ROSCO. Meanwhile, Joe and Sachio settle things once and for all.

It's decided that Mac and Joe will get into the ring together, but Mac finds out something shocking from Maya...

Mac falls into despair when he finds out the truth and encounters a familiar face from his past.

Joe and Mac head into the ring to have their legendary match.